Bulk transcriptome analysis of conditional MYT1L-mutant ESC-derived human induced neurons.

ABSTRACT: We examined the effect of heterozygous MYT1L deficiency in human induced neurons. Increased expression of genes with MYT1L binding motifs and activation of non-neuronal genes were observed in human neurons along with deregulation of autism-associated risk genes upon depletion of MYT1L.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171324 | GEO | 2023/02/14

REPOSITORIES: GEO