ADNP suppresses R-loops at its binding sites

ABSTRACT: We have identified ADNP as an R-loop regulator using a proximity-dependent labeling system. We find that ADNP is necessary to suppress R-loops at its binding sites, and that deletion of the ADNP homeodomain reduces ADNP binding to chromatin and results in R-loop accumulation.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE171401 | GEO | 2021/11/15

REPOSITORIES: GEO