Role of Cop1 on transcriptional output in 4T1 mouse triple negative breast cancer cells

ABSTRACT: Cop1 regulates stability of transcription factors. We determined the role of Cop1 in the regulation of Cebpd transciptional output. We generated 4T1breast cancer cells with CRISPR/Cas9 mediated Cop1 (gene symbol RFWD2) knockout. We treated control sgRosa26 and sgCop1 cells with vehicle or IFNgamma (20ng/ml) for 24 hours and isolated RNA for sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE171467 | GEO | 2021/04/30

REPOSITORIES: GEO