Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer [ATAC-Seq]

ABSTRACT: This study profiles chromatin accessibility, gene expresison, transcription factor binding, and three-dimensional DNA-DNA contact changes upon rapid SWI/SNF ATPase inactivation in prostate cancer cells. SWI/SNF ATPases activity was disabled using a novel PROTAC degrader compound targeting the SMARCA2, SMARCA4 and PBRM1 subunits of the SWI/SNF remodeling complex.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171584 | GEO | 2021/10/28

REPOSITORIES: GEO