Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques

ABSTRACT: In this study, we demonstrate that LAMP5 is essential for proliferation of MLL-rearranged leukemias. Through gene expression changes occurring upon LAMP5 knockdown, we show that LAMP5 maintains an important balance between Type I interferon and NFkB signaling, and that knockdown biases MLL leukemia cells towards activation of the interferon pathway

ORGANISM(S): Macaca mulatta

PROVIDER: GSE171669 | GEO | 2022/04/06

REPOSITORIES: GEO