Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

ABSTRACT: Due to the current opioid epidemic, a better understanding of genetic and environmental factors that contribute to opioid addiction is warranted. To explore the potential causative role of VitD in opioid addiction , we used multiple pharmacologic approaches and genetic mouse models. We used profiled the transcriptome of key brain reward regions upon morphine treatment in vitamin D receptor KO and wild type mice. Our results highlight the role of VitD deficiency in the development of addiction and suggest a potential therapeutic benefit of VitD supplementation for VitD deficient individuals in the prevention and management of addiction.

ORGANISM(S): Mus musculus

PROVIDER: GSE171683 | GEO | 2021/04/25

REPOSITORIES: GEO