Immunomodulatory effects of ponesimod on human astrocytes

ABSTRACT: Ponesimod is a slective S1PR1 antagonist and is approved for the treatment of Multiple Sclerosis by FDA. To determine how ponesimod controls neuroinflammatory responses in astrocytes, single-cell RNA-sequencing (scRNA-seq) was conducted in cytokine mixture-stimulated human primary astrocytes in the presence or absence of ponesimod.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171684 | GEO | 2021/10/08

REPOSITORIES: GEO