Transcriptomics

Dataset Information

21

Hepatic gene expression before and during interferon and ribavirin combination therapy


ABSTRACT: Patients who cleared HCV viremia early during therapy tended to show favorable outcomes, whereas patients who needed a longer period to clear HCV had poorer outcomes. We explored the mechanisms of treatment resistance by comparing hepatic gene expression before and during treatment Overall design: We explored the mechanisms of treatment resistance by comparing hepatic gene expression before and during treatment. Liver biopsy was performed in 30 patients before and one week after starting combination therapy with IFN + Rib. Hepatocytes and liver-infiltrating lymphocytes (LILs) were obtained from 12 patients using laser capture micro dissection (LCM).

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Masao Honda  

PROVIDER: GSE17183 | GEO | 2009-12-31

SECONDARY ACCESSION(S): PRJNA119677

REPOSITORIES: GEO

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