Transcriptional analysis of bone morphogenetic protein 2 signaling in human placental trophoblast development and function

ABSTRACT: Previous studies have demonstrated the pro-invasive action of BMP2 signaling in human trophoblast cells in vitro. In this study, we investigated downstream transcriptional targets of BMP2 signaling using mRNA-sequencing on control and BMP2-treated primary human trophoblast cells (n=5). Gene ontology annotations revealed that differentially expressed genes were involved in multiple organ development and cellular functions. Cell adhesion and extracellular matrix organization were among the significantly associated terms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172040 | GEO | 2022/04/13

REPOSITORIES: GEO