Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

ABSTRACT: mRNA sequencing of pig prefrontal cortex after treatment with one dose of psilocybin or placebo (saline).

ORGANISM(S): Sus scrofa

PROVIDER: GSE172074 | GEO | 2021/04/20

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

gene expression analysis of the rat prefrontal cortex following psilocybin or ketanserin administration

Project description:We report mRNAs differentially expressed in the prefrontal cortex of adult male rats 24 hours following administration of ketanserin and/or psilocybin

2024-06-26 | GSE235175 | GEO

Conserved DNA Methylation Signatures in the Prefrontal Cortex of Newborn and Juvenile Guinea Pigs Following Antenatal Betamethasone Exposure

Project description:We investigated the effect of antenatal corticosteroid exposure (ACS) on the DNA methylation patterns in the prefrontal cortex (PFC) of female guinea pig offspring. Guinea pig dams were treated with saline or betamethasone on gestational days 50/51. PFC was collected from newborn (post-natal day 1) and juvenile (PND 14) offspring. Methylation assessment using genomic DNA was performed with reduced representation bisulfite sequencing techniques.

2024-11-06 | GSE280726 | GEO

Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

Project description:Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

| PRJNA721958 | ENA

Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

Project description:Psilocybin, and other serotonergic psychedelics, have re-emerged as therapeutics for neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on behavior, likely due to its profound ability to alter consciousness and augment neural connectivity and plasticity. Impaired synaptic plasticity in obesity contributes to ‘addictive-like’ behaviors, including heightened motivation for palatable food, and excessive food seeking and consumption. Here, we evaluate the effects of psilocybin on feeding behavior, energy metabolism and as a weight-lowering agent in mice. We demonstrate that a single dose of psilocybin substantially alters the prefrontal cortex transcriptome but has no acute or long-lasting effects on food intake or body weight in diet-induced obese mice or in genetic mouse models of obesity. Similarly, sub-chronic microdosing of psilocybin has no metabolic effects in obese mice and psilocybin does not augment glucagon-like peptide-1 (GLP-1) induced weight loss or enhance diet-induced weight loss. A single high dose of psilocybin reduces sucrose preference but fails to counter binge-like eating behavior. Although these preclinical data discourage clinical investigation, there may be nuances in the mode of action of psychedelic drugs that are difficult to capture in rodent models, and thus require human evaluation to uncover.

2022-08-17 | GSE209859 | GEO

E-GEOD-49028

Project description:Fyn-dependent prefrontal cortex gene networks in acute ethanol sensitivity

2015-07-16 | E-GEOD-49028 | ExpressionAtlas

Effect of psilocybin on visual cortex

Project description:Effect of psilocybin on visual cortex

2025-03-26 | GSE285605 | GEO

Development and evaluation of an autism pig model

Project description:Developing cost-effective and disease-relevant animal models is essential for advancing biomedical research into human disorders. This study investigates the feasibility of a pig model for autism spectrum disorder (ASD) using embryonic exposure to valproic acid (VPA), an antiepileptic drug known to increase ASD risk. We established experimental paradigms to assess the behavioral characteristics of these pig models. Administration of VPA to Bama miniature pigs (Sus scrofa domestica) during critical embryonic stages resulted in abnormal gait, increased anxiety levels, reduced learning capabilities, and altered social patterns, while largely preserving social preference of treated piglets. Notably, we detected significant neuroanatomical changes in cortical regions associated with ASD in the VPA-treated pigs, including cortical malformation, increased neuronal soma size, decreased dendritic complexity, and reduced dendritic spine maturation. Transcriptome analysis of the prefrontal cortex of VPA-treated pigs further revealed substantial alterations in the expression of genes linked to ASD, especially genes of the dopamine signaling pathway, highlighting the model’s relevance and potential for shedding light on ASD’s underlying neuropathological and molecular mechanisms. These findings suggest that pig models could serve as a promising alternative to traditional rodent models and provide an ethical substitute for using primates in the translational research of neurodevelopmental disorders.

2024-11-01 | GSE274270 | GEO

gene expression analysis of the rat prefrontal cortex following psilocybin or ketanserin administration

Project description:gene expression analysis of the rat prefrontal cortex following psilocybin or ketanserin administration

| PRJNA984712 | ENA

Single-nucleus RNA-Seq

Project description:Psilocybin is a psychedelic whose metabolite, psilocin, is a 5-HT2A receptor agonist. Nevertheless, the underlying mechanisms for the therapeutic effect of psilocybin are not fully illustrated, and cell-type-specific and circuit effects of it are not fully understood. Here, we combined single-nucleus RNA-seq with functional assays to study the long-term effects of psilocybin on the orbitofrontal cortex (OFC), a brain region vulnerable to brain disorders such as depression. We demonstrated that a single dose of psilocybin induced long-term genetic and functional changes in neurons in the OFC, and excitatory and inhibitory neurons jointly reduced circuit activity of the brain region.

2024-01-22 | GSE246451 | GEO

single-nucleus RNA-sequencing (snRNA-seq) of ex-vivo-perfused pig kidney cortex tissue

Project description:The pig kidney cortex tissue was collected before and after ex vivo perfusion

2023-01-11 | GSE218413 | GEO