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Polycomb repressive complex 2 (PRC2) function in adult hair follicle stem cells is dispensable for hair regenration

ABSTRACT: Polycomb repressive complexes 2 mediated gene regulation in adult HFSCs is non-instructive for hair regenration

ORGANISM(S): Mus musculus

PROVIDER: GSE172082 | GEO | 2021/11/17

REPOSITORIES: GEO

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Polycomb repressive complex 2 (PRC2) function in adult hair follicle stem cells is dispensable for hair regenration

Project description:Polycomb repressive complex 2 (PRC2) function in adult hair follicle stem cells is dispensable for hair regenration

| PRJNA721969 | ENA

Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration.

Project description: Not available

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Nfatc1 Orchestrates Aging in Hair Follicle Stem Cells

Project description:Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quiescent hair follicle stem cells (HFSCs) were FACS-purified for ChIP-sequcencing.

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Signaling couples hair follicle stem cell quiescence with reduced histone H3K4/K9/K27me3 for proper tissue homeostasis

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