Disease modeling of pulmonary fibrosis using human iPS cell-derived alveolar organoids (SPC+ cells)

ABSTRACT: We developed an in vitro model of pulmonary fibrosis using alveolar organoids, consisting of human induced pluripotent stem cell-derived alveolar epithelial cells and human lung fibroblasts. In this model, fibroblasts were activated by bleomysin (BLM) treatment in an epithelial cell-dependent manner simillar to the pathogenic mechanism observed in pulmonary fibrosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172122 | GEO | 2021/11/19

REPOSITORIES: GEO