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FOXM1-AKT positive regulation loop provides venetoclax resistance in AML

ABSTRACT: FOXM1 and AKT are crucial pro-oncogenic regulators of cancer therapy resistance. Due to reciprocal regulatory links they establish a positive feedback autoregulation loop in AML cells. Disruption of this loop via inhibition of either FOXM1 or AKT results in similar gene expression changes, drastic upregulation of HOXA genes and sensitization of AML cells to cytarabine and venetoclax treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172189 | GEO | 2021/08/18

REPOSITORIES: GEO

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FOXM1-AKT positive regulation loop provides venetoclax resistance in AML

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