Targeted Next-Generation Sequencing for profiling frequently mutated genes in early-stage colon cancer

ABSTRACT: Intratumor heterogeneity fosters the evolution of the genome leading to metastatic progress and therapy resistance. Here, we investigate the relative contribution of genomic heterogeneity involving mutations and CNAs as prognostic and predictive determinants for disease recurrence in early-stage colon cancer. We combined targeted next-generation sequencing (NGS) and SNP arrays on a retrospective cohort of untreated stage II colon cancer patients to assess the association of genomic subclonality with time to recurrence (TTR).

ORGANISM(S): Homo sapiens

PROVIDER: GSE172190 | GEO | 2021/12/01

REPOSITORIES: GEO