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Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

ABSTRACT: Mice rendered obese with high fat diet were treated by IP injection with N-trans caffeoyltyramine (NCT) (200 mg/kg bid) for 14 days, followed by harvesting of the liver for analysis, including RNA isolation.

ORGANISM(S): Mus musculus

PROVIDER: GSE172234 | GEO | 2021/04/17

REPOSITORIES: GEO

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Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

Project description:Mice rendered obese with high fat diet were treated by IP injection with N-trans caffeoyltyramine (NCT) (200 mg/kg bid) for 14 days, followed by harvesting of the intestine for analysis, including RNA isolation.

2021-06-18 | GSE178435 | GEO

Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

Project description:T6PNE human pancreatic cells were treated by DMSO or N-trans caffeoyltyramine (NCT) for 2 days with palmitate, followed by harvesting for RNA isolation.

2021-05-22 | GSE174848 | GEO

Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

Project description:Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

| PRJNA722504 | ENA

Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

Project description:Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

| PRJNA738950 | ENA

Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

Project description:Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

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Tissue transcriptome atlas across DIO and lean mouse tissues

Project description:RNA sequencing was performed on several tissues extracted from 5 lean and 5 diet-induced obese (DIO) mice.

2021-10-13 | GSE185466 | GEO

Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

Project description:Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

| PRJNA511818 | ENA

The Negative Cofactor 2 complex is a master regulator of drug resistance in Aspergillus fumigatus [ChIP-seq]

Project description:The Negative cofactor 2 (NCT) complex is an evolutionally conserved heterodimeric transcription factor. In Aspergillus fumigatus, the NCT complex consists of two subunits NctA and NctB. Through a genome-wide screening of a transcription factor null mutant strains, we found that loss of the NCT complex leads to a multi-drug resistance phenotype including the azoles (itraconazole, voriconazole and posaconazole) as well as the salvage therapeutic amphotericin B, and terbinafine. To obtain further insight into the molecular mechanisms driving the azole-resistance in the NCT complex null mutants, we analyzed genome-wide binding profiles of NctA using chromatin-immunoprecipitation sequencing (ChIP-seq). Our ChIP-seq analysis revealed that NCT complex binds the promoters of several ergosterol biosynthetic genes, their transcriptional regulators, and the azole efflux pump cdr1B. Taken together, these results suggest that the NCT complex plays a role as a master regulator of drug resistance in A. fumigatus.

2019-12-31 | GSE129967 | GEO

scRNAseq of DIO-NASH mouse livers

Project description:To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologically validated diet-induced obese (DIO) NASH mice compared to chow-fed controls. Bulk RNA-sequencing and proteomics showed a clear distinction between phenotypes and a good correspondence between mRNA and protein level regulations, apart from specific regulatory events discovered by each technology. Transcriptomics-based gene set enrichment analysis revealed changes associated with key clinical manifestations of NASH, including impaired lipid metabolism, increased extracellular matrix formation/remodeling and pro-inflammatory responses, whereas proteomics-based gene set enrichment analysis pinpointed metabolic pathway perturbations. Integration with single-cell RNA-sequencing data identified key regulated cell types involved in development of NASH demonstrating the cellular heterogeneity and complexity of NASH pathogenesis.

2020-09-19 | GSE158241 | GEO

Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

Project description:Since leptin signaling in the hypothalamus is critical to regulate food intake and body weight, we investigated how celastrol alters the hypothalamic transcriptome of DIO mice. By doing this analysis, genes with potential relevance for celastrol-mediated leptin sensitization could be identified.

2018-12-27 | GSE124353 | GEO

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