Transcriptomics,Genomics

Dataset Information

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Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury


ABSTRACT: Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. We perfomed scRNAseq on lineage-traced cells resulting from acinar cells upon pancreas injury. Overall design: Acinar cells were lineage-traced with enhanced yellow fluorescent protein (EYFP) to follow their fate upon injury. Mice were sacrificed after either 2 or 4 weeks of caerulein treatment and pancreata were collected. Two mice for each time point. Transcripts of over 13,000 EYFP+ cells were profiled. Single-cell trajectories were generated. Data were compared to gastric metaplasia and human pancreatitis.

INSTRUMENT(S): Illumina NovaSeq 6000 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Zhibo Ma  

PROVIDER: GSE172380 | GEO | 2021-09-30

REPOSITORIES: GEO

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