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Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

ABSTRACT: In the present study, we aimed to discern the preconception decidual transcriptomic signature associated with in vivo defective decidualization in women who suffered sPE in a previous pregnancy. First, we performed a comparative global transcriptional profiling of endometrium from women who developed sPE in a previous pregnancy and from women who never have had sPE. Then, we selected those genes that were significantly deregulated 1.4-fold higher (FDR<0.05) and have an EntrezID code. As a result, we formulate a transcriptional signature associated with defective decidualization composed by 120 genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172381 | GEO | 2021/10/06

REPOSITORIES: GEO

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Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE).

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Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

Project description:Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

| PRJNA723182 | ENA

Homo sapiens

Project description:Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE).

| PRJNA356828 | ENA

Genome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells

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