Disrupted PGR-­B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

ABSTRACT: In the present study, we aimed to discern the preconception decidual transcriptomic signature associated with in vivo defective decidualization in women who suffered sPE in a previous pregnancy. First, we performed a comparative global transcriptional profiling of endometrium from women who developed sPE in a previous pregnancy and from women who never have had sPE. Then, we selected those genes that were significantly deregulated 1.4-fold higher (FDR<0.05) and have an EntrezID code. As a result, we formulate a transcriptional signature associated with defective decidualization composed by 120 genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172381 | GEO | 2021/10/06

REPOSITORIES: GEO