Longitudinal profiling of the whole blood transcriptional response of human volunteers to repeated malaria challenge

ABSTRACT: We took a systems immunology approach to analyse the evolution of the human immune response to the first three infections of life in a re-challenge model of falciparum malaria. Ten volunteers were infected up to three times with Plasmodium falciparum in 4- to 8-month intervals. Remarkably, parasite densities and the dynamics of blood-stage infection were not altered over the course of three homologous infections. To track the development of immunity in real-time we used whole blood RNA-sequencing to analyse each volunteer’s transcriptional response throughout infection and convalescence (up to 9 time points per volunteer per infection).

ORGANISM(S): Homo sapiens

PROVIDER: GSE172450 | GEO | 2021/05/25

REPOSITORIES: GEO