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MicroRNA expression in a model of mouse corticogenesis

ABSTRACT: We established an in vitro model of mouse corticogenesis starting from mouse embryonic stem cells (ESCs). We analyzed miRNAomes of dividing and post-mitotic ESC-cortical cells and miRNAomes of E12 and P0 mouse cortex. By comparing the microRNA expression profiles of progenitors and precursors at different times of in vitro differentiation to the microRNA expression profiles of E12 and P0 mouse cortex we validated the model of mouse in vitro corticogenesis and provided microRNA expression datasets of early mouse embryonic cerebral cortex. Moreover, by the miR-CATCH method we analyzed the enrichement of microRNAs after the binding to the 3’UTR of Satb2. This allowed to identify microRNAs that directly inhibit SATB2 expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE172502 | GEO | 2021/04/22

REPOSITORIES: GEO

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