Hyperactive RAS/MAPK introduces cancer-specific mitotic vulnerabilities

ABSTRACT: We performed tanscriptional profiling of ARPE19 and four isogenic transformed cells lines in which Ras or two downstream pathways, MAPK or PI3K/mTOR, were up-regulated. The purpose of this study is to understand how Ras signaling impacts kinetochore function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172512 | GEO | 2022/09/21

REPOSITORIES: GEO