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Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

ABSTRACT: Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repressed or enhanced by mutant combinations. This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Schizosaccharomyces pombe Saccharomyces cerevisiae

PROVIDER: GSE17298 | GEO | 2009/09/20

SECONDARY ACCESSION(S): PRJNA119033

REPOSITORIES: GEO

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Transcription profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, Affymetrix dataset

Project description:Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repressed or enhanced by mutant combinations. Experiment Overall Design: Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family) in S. pombe. RNA was extracted from the various mutants and hybridized on Affymetrix arrays.

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Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

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2009-09-19 | E-GEOD-17298 | biostudies-arrayexpress

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