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High-throughput lncRNA sequencing profile of ovarian granulosa cells in polycystic ovary syndrome

ABSTRACT: Purpose:To examine different expression profiles of lncRNAs and mRNAs in ovarian granulosa cells (GCs) in PCOS patients and controls Patients:6 GCs samples in each group were subjected to high-thoughput sequencing Results:54,615 lncRNAs and 123,141 mRNAs were detected in this high-thoughput sequencing, and we identified 1049 differential expressed lncRNAs and 3246 mRNAs (fold-change≧2, P-value<0.05). So far, we found 7 lncRNAs and 3mRNAs were validated consistent with sequence profile which were selected, randomly. There is still a large part that we have not verified yet. Conclusion: Our study provides the detail analysis of GCs transcriptomes, generated by high-thoughput technology. This report also provides a framework for comparative investigations of PCOS. Our results revealed the expression of lncRNAs, mRNAs and part of circRNAs in PCOS, after more in-depth research in future, it can provide basic datas for studying the pathogenesis of PCOS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173160 | GEO | 2023/04/20

REPOSITORIES: GEO

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Multiomics analysis reveals molecular abnormalities in granulosa cells of women with polycystic ovary syndrome

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2021-03-08 | GSE168404 | GEO

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IGF2BP2-regulated alternative splicing of NFIC causes excessive granulosa cell proliferation in PCOS [RNA-seq]

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