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Defining the AHR-regulated transcriptome in NK cells reveal gene expression programs relevant to development and function

ABSTRACT: Aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that plays a critical role in shaping innate and adaptive immune responses. However, the molecular mechanism by which AHR regulates the function of human NK cells remains largely unknown. Here, we use RNA sequencing on IL21-expanded NK cells in the presence of AHR agonists and antagonist to demonstrate that AHR directly regulates the expression of known regulators of phenotype, development, metabolism, and function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173220 | GEO | 2021/04/24

REPOSITORIES: GEO

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Hexokinase 2 is a transcriptional targetHexokinase 2 is a transcriptional target and a positive modulator of AHR signalling and a positive modulator of AHR signalling

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