Genomics

Dataset Information

0

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS


ABSTRACT: SF3B1 knockdown in human CD34+ cells leads to increased apoptosis and cell cycle arrest of early-stage erythroid cells and generation of abnormally nucleated late-stage erythroblasts. RNA-seq analysis of SF3B1-knockdown erythroid progenitor CFU-E cells revealed altered splicing of an E3 ligase Makorin Ring Finger Protein 1 (MKRN1) and subsequent activation of p53 pathway.Decreased expression of genes involved in mitosis/cytokinesis pathway including polo-like kinase 1 (PLK1) was noted in SF3B1-knockdown polychromatic and orthochromatic erythroblasts comparing to control cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173232 | GEO | 2021/04/24

REPOSITORIES: GEO

Similar Datasets

2023-04-23 | GSE229589 | GEO
2021-10-13 | GSE159520 | GEO
2020-05-25 | GSE150774 | GEO
2017-09-09 | GSE98375 | GEO
2023-08-09 | GSE232221 | GEO
2016-01-26 | MSV000079482 | MassIVE
2023-09-06 | GSE222368 | GEO
2011-09-13 | E-GEOD-32110 | biostudies-arrayexpress
2023-06-02 | GSE152758 | GEO
2020-04-08 | PXD017657 | Pride