Different hot spot mutations in the TP53 genes exerts different biology and outcome

ABSTRACT: We report that R273 mutation in the TP53 gene in Colorectal cancer promotes transcriptional signature affecting cytoskeleton dynamics and increasing cell migration. This signature is not a general transcriptional output of mutantp53 as other known hot spot such as R175H mutation could not exerts this signature.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173364 | GEO | 2021/09/01

REPOSITORIES: GEO