Hepatocyte-specific perturbation of the NAD+ biosynthetic pathways in mice promotes reversible NASH-like phenotypes

ABSTRACT: We report that the decreased expression of mitochondrial genes we observe in hepatocyte-specific Nampt knockout mice is normalized in primary hepatocytes, and that hepatocyte isolations causes major changes to the hepatocyte transcriptome for both knockouts and wildtype mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE173406 | GEO | 2021/11/03

REPOSITORIES: GEO