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ORC1 binds to cis-transcribed RNAs for efficient activation of human origins [ORC1_FLAG_RIPseq]

ABSTRACT: By investigating the RNA binding activity of human ORC1, we show that it interacts with RNAs transcribed at active origins, which is linked to ORC1 dynamic association to the chromatin and optimal origin firing in S phase.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173448 | GEO | 2023/06/05

REPOSITORIES: GEO

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ORC1 binds to cis-transcribed RNAs for efficient activation of human origins [ORC1_iCLIP]

Project description:By investigating the RNA binding activity of human ORC1, we show that it interacts with RNAs transcribed at active origins, which is linked to ORC1 dynamic association to the chromatin and optimal origin firing in S phase.

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Genome-wide mapping of human DNA-replication origins: levels of transcription at Orc1 sites regulate origin selection and replication timing

Project description:We report the genome-wide mapping of Orc1 binding-sites in mammals and their validation as active DNA-replication origins (ORIs). Orc1 sites are universally associated with transcription start sites (TSSs) of coding or non-coding RNAs. Transcription levels at the Orc1 sites directly correlate with replication timing, suggesting the existence of two classes of ORIs: those associated with moderate/high transcription levels (M-bM-^IM-%1 RNA copy/cell), replicating in early S and mapping to the TSSs of coding RNAs, and those associated with low transcription levels (<1 RNA copy/cell), replicating throughout the entire S and mapping to TSSs of non-coding RNAs. These findings are compatible with a scenario whereby TSS expression-levels influence the efficiency of Orc1 recruitment at G1 and the probability of firing during S. Identification of Orc1 binding sites in human cells

2012-09-18 | E-GEOD-37583 | biostudies-arrayexpress

ORC1 binds to cis-transcribed RNAs for efficient activation of human origins

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-05 | GSE173452 | GEO

Genome-wide mapping of human DNA-replication origins: levels of transcription at Orc1 sites regulate origin selection and replication timing

Project description:We report the genome-wide mapping of Orc1 binding-sites in mammals and their validation as active DNA-replication origins (ORIs). Orc1 sites are universally associated with transcription start sites (TSSs) of coding or non-coding RNAs. Transcription levels at the Orc1 sites directly correlate with replication timing, suggesting the existence of two classes of ORIs: those associated with moderate/high transcription levels (≥1 RNA copy/cell), replicating in early S and mapping to the TSSs of coding RNAs, and those associated with low transcription levels (<1 RNA copy/cell), replicating throughout the entire S and mapping to TSSs of non-coding RNAs. These findings are compatible with a scenario whereby TSS expression-levels influence the efficiency of Orc1 recruitment at G1 and the probability of firing during S.

2012-09-18 | GSE37583 | GEO

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