The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis

ABSTRACT: We found that Keap1-Nrf2 signaling pathway mediates UBR7 to regulate HK2 expression through the modification of histone H2BK120 monoubiquitination, thereby inhibiting glycolysis and HCC tumorigenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE173454 | GEO | 2022/12/09

REPOSITORIES: GEO