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Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity

ABSTRACT: To test wheather cavefish have higher lipogenesis capability than surface fish, we used liver sample from fasted and refed fish to do RNA-seq to compare their transcriptome responding to feeding in surface fish and Pachón cavefish. Moreover, we did the Pparγ ChIP-seq with liver from fed surface fish and Pachón cavefish. We amied to test whether Pparγ in Pachón cavefish have more biding sites and higher binding peaks than surface fish.

ORGANISM(S): Astyanax mexicanus

PROVIDER: GSE173494 | GEO | 2022/02/10

REPOSITORIES: GEO

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Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity

Project description:Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity

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Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation

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