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Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

ABSTRACT: Here, we aim to understand the role of P38 in the airway epithelial cells response to flagellin. We report the gene expression profile of pig airway epithelial cells cultured under air-liquid conditions, pre-incubated or not with the P38 inhibitor SB203580 (20 µM, Tocris Bioscience) for 1 h and then stimulated with 100 ng/ml of a mutated flagellin (FliCΔ174-400) for 2h or 24h. Our data show that flagellin stimulation induce the expression of pro-inflammatory cytokines mainly through the NFkB pathway, with little impact of P38 inhibition in the cells response.

ORGANISM(S): Sus scrofa

PROVIDER: GSE173768 | GEO | 2022/05/21

REPOSITORIES: GEO

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Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

Project description:Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

| PRJNA726987 | ENA

Lung conventional dendritic cells promote mucosal adjuvant activity of flagellin

2014-01-01 | GSE46421 | GEO

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