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Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]

ABSTRACT: Cell-specific transcriptomic analysis were performed on PFC endothelial cells of stress-susceptible (SS) and resilient (RES) mice along with females subjected to 6 days of subchronic variable stress to identify novel genes and pathways involved in stress responses

ORGANISM(S): Mus musculus

PROVIDER: GSE173796 | GEO | 2021/10/29

REPOSITORIES: GEO

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Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure was compared to male [Male_SS_vs_Female_SS_or_SCVS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of stress-susceptible (SS) and resilient (RES) mice along with females subjected to 6 days of subchronic variable stress to identify novel genes and pathways involved in stress responses. These gene lists were compared to published findings obtained in the male NAc following 10 days of chronic social stress exposure (Dudek et al., 2020)

2021-10-29 | GSE173797 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress exposure [Female_CSDS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of unstressed controls (CTRL), stress-susceptible (SS) and resilient (RES) mice to identify novel genes and pathways involved in stress responses

2021-10-29 | GSE173794 | GEO

Expression (Gene) in the endothelial cells of the mouse male prefrontal cortex (PFC) following 10-day chronic social stress exposure [male CSDS]

2021-10-29 | GSE182671 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 6-day subchronic variable stress (SCVS) exposure [Female_SCVS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of unstressed controls (CTRL) and mice exposed to SCVS to identify novel genes and pathways involved in stress responses

2021-10-29 | GSE173795 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]

Project description:Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]

| PRJNA727167 | ENA

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

Project description:Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in female mice, whereas males are resilient as they do not develop these behavioral abnormalities. In concert with these different behavioral responses, transcriptional analysis of nucleus accumbens (NAc), a major brain reward region, by use of RNA sequencing (RNA-seq) revealed markedly different patterns of stress regulation of gene expression between the sexes. Among the genes displaying sex differences was DNA methyltransferase 3a (Dnmt3a), which shows a greater induction in females after SCVS. Interestingly, Dnmt3a expression levels were increased in the NAc of depressed humans, an effect seen in both males and females. Local overexpression of Dnmt3a in NAc rendered male mice more susceptible to SCVS, whereas Dnmt3a knock-out in this region rendered females more resilient, directly implicating this gene in stress responses. Associated with this enhanced resilience of female mice upon NAc knock-out of Dnmt3a was a partial shift of the NAc female transcriptome toward the male pattern after SCVS. These data indicate that males and females undergo different patterns of transcriptional regulation in response to stress and that a DNA methyltransferase in NAc contributes to sex differences in stress vulnerability. mRNA profiles of sex-specific in stress response were generated in the Nucleus Accumbens for 3 female control mice, 3 male control mice, 3 stressed female mice, 3 stressed male mice. Cre-mediated Dnmt3a knock-out was performed on stressed mice, with 3 males and 3 females expressing control GFP and 3 males and 3 females expressing CRE/GFP.

2016-08-04 | E-GEOD-85136 | biostudies-arrayexpress

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

2016-08-04 | GSE85136 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 6-day subchronic variable stress (SCVS) exposure [Female_SCVS]

Project description:Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 6-day subchronic variable stress (SCVS) exposure [Female_SCVS]

| PRJNA727163 | ENA

| PRJNA727161 | ENA

Expression data from ileum of mice suffered from subchronic and mild social defeat stress

Project description:This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to investigate the effect of social defeat stress on not only central nervous system but also function of gastrointestinal tract, the gene expression in ileum of stressed mice was compared with control mice. We used microarrays to detail the gene expression after 10 days of social defeat stress and identified distinct classes of down-regulated genes during this process.

2016-08-03 | GSE64004 | GEO

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