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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

ABSTRACT: We report RNA sequencing data that shows the differential effects of HLA-DRb1*0301 (LE), HLA-DRb1*0401 (SE) and HLA-DRb1*0402 (PE) on macrophage gene expression under IFNγ cell culture conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE173875 | GEO | 2022/08/03

REPOSITORIES: GEO

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	GSE173875_deSeq2_counts_RAW264.7_cells_IFNy_LE_SE_PE.txt.gz	Txt

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The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [THP-1]

Project description:We report RNA sequencing data that shows the differential effects of HLA-DRb1*0301 (LE), HLA-DRb1*0401 (SE) and HLA-DRb1*0402 (PE) on macrophage gene expression under IFNγ cell culture conditions.

2022-08-03 | GSE173876 | GEO

Antigen Presentation-Independent Reciprocal Immune Modulation by HLA-DRB1 Allelic Epitopes that Associate with Autoimmune Disease Risk or Protection in Human Macrophages

Project description:We report RNA sequencing data that shows the the differential effects of HLA-DRb1*0401 (SE) and HLA-DRb1*0402 (PE) on marcophage gene expression under M1 polarizing cell culture conditions

2021-02-02 | GSE159279 | GEO

Antigen Presentation-Independent Reciprocal Immune Modulation by HLA-DRB1 Allelic Epitopes that Associate with Autoimmune Disease Risk or Protection in Murine Macrophages

Project description:We report RNA sequencing data that shows the differential effects of HLA-DRb1*0401 (SE) and HLA-DRb1*0402 (PE) on macrophage gene expression under M1 and M2 polarizing cell culture conditions.

2021-02-02 | GSE159820 | GEO

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope.

Project description: Not available

| S-EPMC9334592 | biostudies-literature

The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-03 | GSE173877 | GEO

The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

Project description:The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope [RAW264.7]

| PRJNA727351 | ENA

Effects of HLA DRB1*15:01 interactions with ⍺-syn32-46 on gene expression in the ileum

Project description:HLA DRB1*15:01 is overrepresentated in Parkinson's disease patients and binds with high affinity to the ⍺-synuclein peptide, 32-46. Immunization of humanized mice expressing HLA DRB1*15:01 with ⍺-syn32-46 induces enteric phenotypes similar to those of prodromal Parkinson's disease. We collected the ileum from HLA mice immunized with either Complete Freund's Adjuvant (CFA) with ⍺-syn32-46 or CFA alone, and sequenced the tissue with bulk RNA sequencing at 21 days post immunization to determine changes in gene expression.

2023-08-17 | GSE231873 | GEO

The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

Project description:The lupus susceptibility allele DRB1*03:01 encodes a disease driving epitope

| PRJNA727339 | ENA

Effects of HLA DRB1*15:01 interactions with ⍺-syn32-46 on gene expression in intestinal immune cells in mice

Project description:HLA DRB1*15:01 is overrepresentated in Parkinson's disease patients and binds with high affinity to the ⍺-synuclein peptide, 32-46. Immunization of humanized mice expressing HLA DRB1*15:01 with ⍺-syn32-46 induces enteric phenotypes similar to those of prodromal Parkinson's disease. We collected the small intestines from HLA mice immunized with either Complete Freund's Adjuvant (CFA) with ⍺-syn32-46 or CFA alone, sorted the CD45+ immune cells, then performed single-cell RNA sequencing to evaluate gene expression at single cell resolution.

2023-08-17 | GSE233572 | GEO

The HLA-DRB1*03:01 ligandome is highly conserved on N- and C-terminal residues outside the peptide-binding cleft

Project description:Human CD4+ T lymphocytes play an important role in inducing potent immune responses. They are activated and stimulated by peptides presented in Major Histocompatibility Complex Class II molecules. These MHC class II molecules typically present peptides of between 12 and 20 amino acids in length. The region that interacts with the MHC molecule, designated as the binding core, is highly conserved in the residues which anchor the peptide to the molecule. In addition, as these peptides are the product of proteolytic cleavages, certain conserved residues may be expected at the N- and C-termini outside the binding core. To study whether similar conserved residues are present in different types of cells , the ligandomes of HLA-DRB1*03:01 derived from two different cell types (dendritic cells and EBV-transformed B-cells) were identified with mass spectrometry and the binding core and N- and C-terminal residues were analysed using the frequencies of the amino acids in the human proteome. Similar binding motifs were found as well as comparable conservations in the N- and C-terminal residues. Furthermore, these terminal conservations of the HLA-DRB1*03:01 ligandome were compared to the N- and C-terminal conservations of the HLA-DRB1*04:01 ligandome acquired from dendritic cells. Again, comparable conservations were evident with only minor differences. Taken all together, these analyses show that there are conservations in the terminal residues of peptides, presumably the result of the activity of proteases involved in antigen processing.

2019-09-16 | PXD014253 | Pride

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