RNAseq of ST6GAL1-wild type and ST6GAL1-knock out cells of MDA-MB-231 cells.
Ontology highlight
ABSTRACT: Dynamic change of glycosylation is found in various cancers; however, the precise role of glycosylation in metastasis is remained largely unknown. Current study show that α2,6-sialylation or β-galactoside α2,6-sialyltransferase (ST6Gal1) inhibits circulating tumor cell aggregation and depletion or restoration of α2,6-sialylation in patient derived xenograft model amplified or diminished cell aggregation and lung metastasis.
ORGANISM(S): Homo sapiens
PROVIDER: GSE174080 | GEO | 2022/12/01
REPOSITORIES: GEO
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