Single-cell RNA Sequencing Reveals Transcriptional Signatures and Cell-cell crosstalk in Patients with Hypertensive Nephropathy

ABSTRACT: Hypertensive nephropathy (HTN) is one of the leading causes of end-stage renal disease, yet the precise mechanisms and cell-specific gene expression changes are still unknown. This study used single-cell RNA sequencing (scRNA-seq) to explore novel molecular mechanisms and gene targets for HTN.Our data identifies a distinct cell-specific gene expression profile, pathogenic signaling pathways and potential cell-cell communications in the pathogenesis of HTN. These findings will provide a promising novel landscape for mechanisms and treatment of HTN.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174219 | GEO | 2022/05/04

REPOSITORIES: GEO