Genomics

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Identification of 5'isomiR in HCC patients.


ABSTRACT: The microRNA (miRNA) processing is a critical step for production of mature miRNAs. Its dysregulation leads to the increase of miRNA isoforms with heterogenous 5’ ends (isomiRs), recognizing distinct target sites with a shifted seed sequence. Although some miRNA genes display productive expression of their 5’-isomiRs in cancers, how the production is controlled and how they impact on tumor progression are unexplored yet. In this study, we identified tumor-specific production of isomiRs and investigated biological function of isomiRs in liver cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174608 | GEO | 2021/05/19

REPOSITORIES: GEO

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