Genomics

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Studying the effects of endogenous and exogenous histidine supplementation on Pichia pastoris cultured in YPA


ABSTRACT: A histidine prototrophic strain achieves A600 three-four fold higher than a histidine auxotroph when cultured in nutrient rich media YPA, which is abundant in amino acids. This retaded growth of histidine auxotroph in YPA can also be rescued by supplementing media with exogenous histidine. Here, we aim to study the transcriptomic changes associated with culturing of histidine auxotroph and prototroph in YPA and also the effects of histidine addition to the culture medium of histidine auxotroph.

ORGANISM(S): Komagataella pastoris

PROVIDER: GSE174633 | GEO | 2022/04/06

REPOSITORIES: GEO

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