Common features of aging fail to occur in Drosophila raised without a bacterial microbiome

ABSTRACT: By comparing the transcriptomes of Drosophila raised either under conventional conditions or in the complete absence of bacteria, we find that 70% of the transcriptional changes that normally occur with age are actually adaptive responses to the microbiome, not unavoidable features of aging. In the germ-free state, these seemingly ‘age-dependent’ gene expression changes never happen.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE174854 | GEO | 2021/05/22

REPOSITORIES: GEO