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Genome-wide transcriptome profiling of human Liver-Chip model of alcohol-associated liver disease (ALD) using RNA-seq.

ABSTRACT: The goal of this study was to assess RNA expression in human primary hepatocytes in response to ethanol exposure compared to control. The hepatocytes were cultured in co-culture on a Liver-Chip model with Kupffer cells and Liver sinusoidal endothelial cells (LSECs) and treated with 0.08% to 0.16% ethanol for 48h.

ORGANISM(S): Homo sapiens

PROVIDER: GSE175396 | GEO | 2021/05/25

REPOSITORIES: GEO

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Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

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