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Generation of functional ciliated cholangiocytes from human pluripotent stem

ABSTRACT: We report on the successful generation of functional ciliated cholangoocytes from hPSCs that will provide new opportunities to study and treat diseases of the liver. Both monolayer- and organoid-derived cells are adaptable for further bioengineering approcahes to produce more complex hPSC-deived liver tissue with biliary ductal structures. Additionally, the successful engraftment of differentiated cholangiocytes in the liver of immune-imcompetent mice provides the basis for developing novel therapeutic strategies to treat cholangiopathies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE175502 | GEO | 2021/10/03

REPOSITORIES: GEO

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Generation of functional ciliated cholangiocytes from human pluripotent stem

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