The MLL-Menin interaction is a molecular dependency in NUP98-rearranged AML [BioChIP-seq]

ABSTRACT: Using mouse and human models of NUP98-rearrranged leukemia, we demonstrate that inhibition of MLL-Menin impairs leukemogenic gene expression and disrupts chromatin binding of MLL1 and NUP98 fusion proteins at a critical subset of genes that is essential for sustaining the undifferentiated leukemia phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE175594 | GEO | 2022/06/01

REPOSITORIES: GEO