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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

ABSTRACT: To identify genes regulating the jamming transition in healthy distal airway epithelia compared to the dysregulated state in idiopathic pulmonary fibrosis epithelia (IPF) we analyzed RNA from three (3) healthy and four (4) IPF patient cells grown at air-liquid-interface (ALI). This bulk analysis of 3 timepointes (days 4, 8, and 14 of ALI) spanning the jamming transition revealed an enrichment for ERBB- and YAP-related genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE176001 | GEO | 2021/07/01

REPOSITORIES: GEO

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