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Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Danio rerio

PROVIDER: GSE176037 | GEO | 2021/12/02

REPOSITORIES: GEO

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Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [I]

Project description:Clonal hematopoiesis (CH) results from enhanced fitness of a mutant hematopoietic stem and progenitor cell (HSPC), but how such clones expand is unclear. Here, we developed a technique that combines mosaic mutagenesis with color labeling of HSPCs to study how acquired mutations affect clonal fitness in a native environment. Mutations in CH-associated genes, like asxl1, promoted clonal dominance. Single-cell transcriptional analysis revealed that mutations stimulated expression of proinflammatory genes in mature myeloid cells and anti-inflammatory genes in progenitor cells of the mutant clone. Biallelic loss of one such immunomodulator, nr4a1, abrogated the ability of asxl1-mutant clones to establish clonal dominance. These results support a model where clonal fitness of mutant clones is driven by enhanced resistance to inflammatory signals from their mutant mature cell progeny.

2021-12-02 | GSE150373 | GEO

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [II]

2021-12-02 | GSE176036 | GEO

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

Project description:Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

| PRJNA734615 | ENA

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [II]

Project description:Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [II]

| PRJNA734619 | ENA

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [I]

Project description:Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [I]

| PRJNA631927 | ENA

Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-01 | E-GEOD-39418 | biostudies-arrayexpress

Clonal hematopoiesis is driven by aberrant activation of TCL1A

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-20 | GSE205637 | GEO

Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

Project description: Not available

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SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-19 | GSE230155 | GEO

Identifying non-genetic determinants of malignant clonal fitness at single cell resolution

Project description:This SuperSeries is composed of the SubSeries listed below.

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