PRBM1 inactivation promotes upregulation of human endogenous retroviruses in a HIF-dependent manner

ABSTRACT: By analyzing RNAseq data derived from TCGA and clinical trial in ccRCC we observed that PBRM1 mutation is significantly associated with expression changes of hERVs (human endogenous retroviruses). We validated this observation in UMRC2 cell line and further demonstrated that PBRM1 specifically regulated members of HERVERI superfamily. We found that the increased expression of hERVs by loss of PBRM1 reversed by further knocking down HIF complex. Our data indicated a role of PBRM1 in negative regulation of selective hERVs in a HIF-dependent manner

ORGANISM(S): Human endogenous retroviruses Homo sapiens

PROVIDER: GSE176053 | GEO | 2021/12/23

REPOSITORIES: GEO