Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)
ORGANISM(S): Mus musculus
SUBMITTER: Gordon K Smyth
PROVIDER: GSE176116 | GEO | 2021-12-22
REPOSITORIES: GEO
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Zhan Yifan Y Zhang Yuxia Y Zhang Shengbo S Coughlan Hannah H Baldoni Pedro L PL Jacquelot Nicolas N Cao Wang H J WHJ Preston Simon S Louis Cynthia C Rautela Jai J Pellegrini Marc M Wicks Ian P IP Alexander Warren S WS Harrison Leonard C LC Lew Andrew M AM Smyth Gordon K GK Nutt Stephen L SL Chopin Michaël M
Science immunology 20210917 63
Dendritic cells (DCs) and macrophages are at the forefront of immune responses, modifying their transcriptional programs in response to their tissue environment or immunological challenge. Posttranslational modifications of histones, such as histone H3 lysine-27 trimethylation (H3K27me3) by the Polycomb repressive complex 2 (PRC2), are tightly associated with epigenetic regulation of gene expression. To explore whether H3K27me3 is involved in either the establishment or function of the mononucle ...[more]