Transcriptional profiling of mouse liver of PPARgamma null mice

ABSTRACT: We highlight sex dimorphism of NAFLD in a lipodystrophic mouse model obtained via total body deletion of PPARγ. The hepatic sex dimorphism is characterized by a more important hepatosteatosis in females compared to males, and is PPARγ- and sex-hormone-dependent. To characterize the molecular mechanisms underlying this phenotype microarray analysis of gene expression was performed in the liver of 7 and 20 week old mice, before and after the onset of the the hepatic sex-dimorphism.

ORGANISM(S): Mus musculus

PROVIDER: GSE176226 | GEO | 2021/09/13

REPOSITORIES: GEO