Host gene expression profiling of fungal (candidemia), bacterial, and viral infection, and non-infectious illness [discovery cohort]

ABSTRACT: Improved diagnostics are necessary to differentiate between multipe potential etiologies of acute illness in a hospitalized patient. The peripheral blood host gene expression response can act as a supplementary diagnostic tool and better inform the full host immune response to a pathogen. We performed RNA sequencing on peripheral blood from 48 hospitalized patients with confirmed candidemia as well as patients with other acute viral, bacterial, and non-infectious illnesses and derived pathogen class-specific gene expression classifiers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE176260 | GEO | 2021/06/08

REPOSITORIES: GEO