Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
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ABSTRACT: Previous studies showed that the anti-rheumatic agent auranofin inhibits the NLRP3 inflammasome; thus, this study evaluate the anti-fibrotic effect of auranofin in vivo and explored the underlying molecular mechanism. The antifibrotic effect of auranofin is assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. In this study, we use RNA-sequencing in hepatic stellate cell (HSC), and bone marrow-derived macrophage (BMDM) to examine the underlying mechanism of auranofin.
ORGANISM(S): Mus musculus
PROVIDER: GSE176346 | GEO | 2021/06/08
REPOSITORIES: GEO
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