Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

ABSTRACT: Previous studies showed that the anti-rheumatic agent auranofin inhibits the NLRP3 inflammasome; thus, this study evaluate the anti-fibrotic effect of auranofin in vivo and explored the underlying molecular mechanism. The antifibrotic effect of auranofin is assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. In this study, we use RNA-sequencing in hepatic stellate cell (HSC), and bone marrow-derived macrophage (BMDM) to examine the underlying mechanism of auranofin.

ORGANISM(S): Mus musculus

PROVIDER: GSE176346 | GEO | 2021/06/08

REPOSITORIES: GEO