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Resident memory T cells in regional lymph nodes sustain immunity to cancer

ABSTRACT: While immune responses against primary tumors are critically important, T cells must also be capable of functioning at sites where cancers metastasize. Here we investigated how resident memory (TRM) and circulating memory (TCIRCM) CD8 T cells potentiate immunity to cancer in diverse tissue microenvironments. Based on a mouse model of immunity to melanoma with associated autoimmune vitiligo, we show that tumor-specific memory T cells form a widespread network of transcriptionally distinct subsets throughout lymphoid tissues and visceral organs. Among these, we discovered a population of TRM cells that reside durably within LNs, where they protect against invading melanoma cells. These LN-resident memory (LN TRM) cells adopt a transcriptional program that is distinct from TRM cells in other tissues, and which uniquely predicts survival in melanoma patients with regional LN metastases. This work reveals a novel role for TRM cells in durable immunity to cancer at crucial sites of metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE176487 | GEO | 2025/06/04

REPOSITORIES: GEO

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Single cell RNA-seq of tumor antigen specific CD8 Tissue Resident Memory (Trm) Cells

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