Imetelstat is effective in Acute Myeloid Leukemia (AML) patient xenografts.

ABSTRACT: Imetelstat is a covalently lipidated 13-mer thiophosphoramidate oligonucleotide that competitively inhibits telomerase activity. Here, we show that imetelstat effectively diminishes AML burden and prolongs survival in a comprehensive, randomized Phase II-like preclinical trial in AML patient-derived xenografts (PDX).

ORGANISM(S): Homo sapiens

PROVIDER: GSE176523 | GEO | 2023/07/14

REPOSITORIES: GEO