Dataset Information


Human peripheral blood cells: autoimmune diseases vs. healthy individuals

ABSTRACT: Gene expression profiling of peripheral blood cells from patients with rheumatoid arthritis (RA)/ systemic lupus erythematosus (SLE)/ polyarticular type juvenile idiopathic arthritis (polyJIA)/ systemic-onset JIA (sJIA) vs healthy children (HC) and healthy individual (HI). Overall design: Peripheral blood was obtained from patients with RA (n=112), SLE (n=22), polyJIA (n=6), sJIA (n=51), HC (n=8), and HI (n=45). Blood samples from 8 HC and 45 HI are used as control.

INSTRUMENT(S): Hitachisoft AceGene Human Oligo Chip 30K 1 Chip Version

SUBMITTER: Norihiro Nishimoto  

PROVIDER: GSE17755 | GEO | 2010-08-21



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Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus.

Lee Hooi-Ming HM   Sugino Hidehiko H   Aoki Chieko C   Nishimoto Norihiro N  

Arthritis research & therapy 20110415 2

INTRODUCTION: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various systemic symptoms and multiple organ damage. We clarify biological and functional abnormalities in SLE by comparing the gene expression profiles of SLE patients with those of healthy individuals. METHODS: Gene expression profiles from the peripheral blood of 21 SLE patients and 45 healthy individuals were obtained using a DNA microarray. Gene ontology analysis and network pathway analys  ...[more]

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